RAPID COMMUNICATION BB-10010: An Active Variant of Human Macrophage Inflammatory Protein-la With Improved Pharmaceutical Properties
نویسندگان
چکیده
The stem cell inhibitor, macrophage inflammatory proteinla (MIP-la) or LD78, protects multipotent hematopoietic progenitors in murine models from the cytotoxic effects of chemotherapy. Clinical use of human MIP-la during chemotherapy could therefore lead to faster hematologic recovery and may allow dose intensification. We have also shown that human MIP-la causes the rapid mobilization of hematopoietic cells, suggesting an additional clinical use in peripheral blood stem cell transplantation. However, the clinical evaluation of human MIP-la is complicated by its tendency to associate and form high molecular weight polymers. We have produced a variant of rhMIP-la, BB-10010, carrying a
منابع مشابه
Evaluation of cytotoxic and apoptotic effects of linoleic acid from Nigella sativa seeds on human ovary carcinoma cell line
Background and objectives: Black cumin is a herbaceous plant with scientific name Nigella sativa, that contains compounds such as fixed oils, proteins, alkaloids, saponins and essential oils. It has numerous health benefits including antioxidant and anti-inflammatory properties. In the current study, we have evaluated the cytotoxic effects of compounds isolated from th...
متن کاملAn Improved GC Method for Rapid Analysis of Valproic Acid in Human Plasma Without Derivatization
A simple, reproducible and rapid gas chromatographic method for precise determination of valproic acid (VPA) in human plasma has been developed. Total time for sample preparation and GC analysis is less than 45 min. After plasma protein precipitation, VPA was extracted into chloroform with suitable recovery. By using Stabilwax®<span styl...
متن کاملDevelopment and evaluation of macrophage targeted multidrug therapy against visceral leishmaniasis
In this study, we fabricated PCL-nanoparticles by encapsulating dual drugs as amphotericin B and doxorubicin via double-emulsion solvent evaporation method also incorporated with ligand-lectin for targeting the infested macrophage cells and prove importance against VL. Different independent processing parameters were assessed systematically to enhance the incorporation of the dual agents with d...
متن کاملEffect of crocin, an active saffron constituent, on ethanol toxicity in the rat: histopathological and biochemical studies
Objective(s): The drinking of ethanol causes the wide range of clinical illness and morphological changes including hepatotoxicity and nephrotoxicity. In the current study, the protective properties of crocin versus oxidative stress, apoptosis and inflammation induced by ethanol were assessed. Materials and Methods: The male Wistar rats ...
متن کاملAnti-inflammatory Effects of PMX205 in Mouse Macrophage Periodontitis Model
Background: C5areceptor antagonistPMX205 is a synthetic hexapeptidecapable of blocking C5a-C5a receptor (C5aR) axis by simulating C5a active C-terminal amino acid residues. This hexapeptide presents good anti-inflammatory effects in a myriad inflammation models. The anti-inflammatory effect of PMX205 on periodontitis is yet to be fully fathomed. Objective: To examine the anti-inflammatory effec...
متن کامل